Pierre Moffatt PhD is an Associate Professor at the Faculty of Dental Medicine and Oral Health Sciences of McGill University, and scientist at the Shriners Hospitals for Children – Canada. He is a member of the MUHC-RI and the Department of Human Genetics. His expertise and interests cover molecular, cellular, and physiological aspects of calcified tissues and rare musculo-skeletal syndromes. His current interests focus mainly on BRIL, a protein expressed in bone forming cells. Mutations in IFITM5/BRIL cause osteogenesis imperfecta (brittle bone disease), and his lab aims at understanding the pathogenic mechanisms in cellular and animal models. Genetically engineered mice that express Ifitm5 variants are being studied as pre-clinical systems. In collaboration with clinicians, he also works on the validation of genetic variants in other rare forms of low bone mass and short stature syndromes.